Compound Found in Grapes May Combat Age-Related Memory Loss
Posted on Thursday, February 19 @ 00:00:00 EST by dhf

DHF Blog Resveratrol, a compound found in the skin of red grapes, red wine, peanuts, and some berries, may be effective for treating age-related declines in memory and mood function, according to a recent study in the online Scientific Reports. This could potentially help patients with Alzheimer’s disease.

Researchers tested the effects of resveratrol in a group of aged rats against a group of controls.

“The results of the study were striking,” said researcher Ashok K. Shetty, PhD, director of neurosciences at the Institute for Regenerative Medicine at Texas A&M Health Science Center College of Medicine. “They indicated that for the control rats who did not receive resveratrol, spatial learning ability was largely maintained but ability to make new spatial memories significantly declined between 22 and 25 months. By contrast, both spatial learning and memory improved in the resveratrol-treated rats."

Researchers also reported mood function improvements in resveratrol-treated rats compared with declines in controls. In addition, treated rats showed nearly double the growth and development of neurons, improved blood flow, and diminished chronic inflammation in the hippocampus compared to rats that did not receive resveratrol.

“The study provides novel evidence that resveratrol treatment in late middle age can help improve memory and mood function in old age,” Dr. Shetty said.

—Jolynn Tumolo


1. Kodali M, Parihar VK, Hattiangady B, Mishra V, Shuai B, Shetty AK. Resveratrol prevents age-related memory and mood dysfunction with increased hippocampal neurogenesis and microvasculature, and reduced glial activation. Scientific Reports. 2015 Jan. 28.

2. Compound found in grapes, red wine may help prevent memory loss [press release]. Newswise: Charlottesville, VA; Feb. 4, 2015.

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